MEB-1170
Treats pain without opioid adverse effects
Active in 3 Rodent Pain Models

No Respiratory Depression

Devoid of Issues Seen in Marketed Opioids:
- Does not produce tolerance to analgesia
- Does not cause constipation
- Does not cause sedation
- No toxicity seen in observational reads
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- Oral with long half-life
- As efficacious as morphine
- Confirmed in 3 in vivo pain models
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- Formalin Induced Pain
- Post Incisional Pain
- Tail Flick
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- Acute and chronic oral dosing
- Normal pO2, pCO2, pH
- Normal respiratory drive
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- Respiratory Rate
- Minute Volume
- Tidal Volume
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1. Comprehensive data package available
Shows no abuse potential in preclinical module
No Drug Seeking Behavior

No Self-Administration

Minimal Withdrawal

Drug Discrimination

Prevent and treat opioid abuse
MEB-1170 has the potential to prevent and to treat opioid abuse in patients undergoing pain therapy
Rats abusing Oxycodone do not abuse MEB-1170
Rats using MEB-1170 do not abuse Oxycodone


indication for meb-1170 (2)
MEB-1170 to treat opioid use disorder
1. Treatment of opioid abuse
2. Replacement of Schedule II opioids in pain management algorithm