The Proprietary Platform of 19 Fluid

1. Detect fluid/solution dynamic conformation of full length GPCRs

    • Proprietary purification of native, full-length GPCR
    • Protein NMR with proprietary 19F labeling scheme to capture coupling of scaffold proteins (G-protein, beta-arrestin) to GPCR

2. Empowers drug discovery beyond current state of the art

3. Platform is agnostic to therapeutic area

4. Successfully applied to multiple targets

    • MOR, DOR
    • S1PR1
    • b1AR, b2AR
    • Additional GPCRs have been expressed and purified as potential targets  (e.g., MLNR, A2A)

Uncovering Extremely ‘Biased’ MOR Agonists