Novel Mechanism to treat Neuroinflammation


“Biased” agonists will prolong duration of action to treat neuroinflammation

Neuroinflammation is involved in the pathophysiology of:

  • Neuropathic Pain
  • Traumatic Brain Injury
  • Parkinson’s Disease
  • Alzheimer’s Disease
  • Multiple Sclerosis
  • Neurodegenerative Diseases

Current Status of Mebias S1PR1 Program


  1. G-protein ‘bias’ SAR established using 19Fluid
  2. Desired potency in cAMP signaling pathway
  3. Drug-like properties

Analgesic Efficacy in rats (formalin model)