Novel Mechanism to treat Neuroinflammation


“Biased” agonists will prolong duration of action to treat neuroinflammation

Neuroinflammation is involved in the pathophysiology of:

  • Neuropathic Pain
  • Traumatic Brain Injury
  • Parkinson’s Disease
  • Alzheimer’s Disease
  • Multiple Sclerosis
  • Neurodegenerative Diseases

Current Status of Mebias S1PR1 Program


  • G-protein ‘bias’ SAR established using 19Fluid
  • Desired potency in cAMP signaling pathway
  • Drug-like properties

Analgesic Efficacy in rats (formalin model)