S1PR1
Novel Mechanism to treat Neuroinflammation
“Biased” agonists will prolong duration of action to treat neuroinflammation
Neuroinflammation is involved in the pathophysiology of:
- Neuropathic Pain
- Traumatic Brain Injury
- Parkinson’s Disease
- Alzheimer’s Disease
- Multiple Sclerosis
- Neurodegenerative Diseases

Current Status of Mebias S1PR1 Program
- G-protein ‘bias’ SAR established using 19Fluid
- Desired potency in cAMP signaling pathway
- Drug-like properties


Analgesic Efficacy in rats (formalin model)
